R&D Publications

Learn about the pharmaceutical publications that members of our R&D team have authored or contributed to.


Atkinson, Hartley C., Ioana Stanescu, Chris Frampton, Isam I. Salem, Charles P. H. Beasley, and Richard Robson. “Pharmacokinetics and Bioavailability of a Fixed-Dose Combination of Ibuprofen and Paracetamol after Intravenous and Oral Administration.” Clinical Drug Investigation, September 3, 2015. doi:10.1007/s40261-015-0320-8.

Atkinson HC, Stanescu I, Beasley CPH, Salem II, Frampton C. “A pharmacokinetic analysis of a novel fixed dose oral combination of paracetamol and ibuprofen, with emphasis on food effect.” Journal of Bioequivalence & Bioavailability. (2015) 7:3.

Atkinson HC, Currie J, Moodie J, Carson S, Evans S, Worthington JP, Steenberg LJ, Bisley E, & Frampton C. “Combination paracetamol and ibuprofen for pain relief after oral surgery: a dose ranging study” (2015) Eur J Clin Pharmacology 71(5) 579-587

Atkinson HC, Stanescu I, Salem II, Potts AL, Anderson BJ. “Increased bioavailability of phenylephrine by co-administration of acetaminophen: results of four open-label, crossover pharmacokinetic trials in healthy volunteers. Eur J Clin Pharmacol (2015) 71(2):151-8

Atkinson HC, Stanescu I, & Anderson BJ. “Increased Phenylephrine Plasma Concentration When Given In Combination with Acetaminophen.” New England Journal of Medicine (2014) N Engl J Med 370(12):1171-1172

Herasimtschuk A, Downey J, Nelson M, Moyle G, Mandalia S, Sikut R, Adojaan M, Stanescu I, Gotch F, Imami N. “Therapeutic immunisation plus cytokine and hormone therapy improves CD4 T-cell counts, restores anti-HIV-1 responses and reduces immune activation in treated chronic HIV-1 infection.” Vaccine (2013) 32(51):7005-13

Vardas E, Stanescu I, Leinonen M, Ellefsen K, Pantaleo G, Valtavaara M, Ustav M, Reijonen K. “Indicators of therapeutic effect in FIT-06, a Phase II trial of a DNA vaccine, GTU(®)-Multi-HIVB, in untreated HIV-1 infected subjects.” Vaccine (2012) 30(27): 4046-54

Martinon F., Kaldma K., Sikut R., Culina S., Romain G., Tuomela M., Adojaan M., Männik A., Toots U., Kivisild T., Morin J., Brochard P., Delache B., Tripiciano A., Ensoli F., Stanescu I., Le Grand R., Ustav M. “Persistent immune responses induced by a human immunodeficiency virus DNA vaccine delivered in association with electroporation in the skin of nonhuman primates.” Human Gene Therapy (2009) 20(11): 1291-1307

Bråve A., Hallengärd D., Malm M., Blazevic V., Rollman E., Stanescu I., Krohn K. “Combining DNA technologies and different modes of immunization for induction of humoral and cellular anti-HIV-1 immune responses.” Vaccine (2009) 27(2):184-6.

Krohn K., Stanescu I., Blazevic V., Vesikari T., Ranki A., Ustav M. “A DNA HIV-1 vaccine based on a fusion gene expressing non-structural and structural genes of consensus sequence of the A–C subtypes and the ancestor sequence of the F–H subtypes.” Preclinical and clinical studies. Microbes and Infection (2005) 7(14):1405-13.

Tuomela M., Stanescu I., Krohn K. “Validation overview of bio-analytical methods.” Gene Therapy (2005) 12. Suppl 1:S131-8

Tuomela M., Malm M., Wallen M., Stanescu I., Krohn K., Peterson P. “Biodistribution and general safety of a naked DNA plasmid, GTU®-MultiHIV, in a rat, using a quantitative PCR method.” Vaccine (2005) 23 (7):890-6

Ionescu G., Damian M., Lucinescu S., Stanescu I., Shundi L., Coşman M., Neguţ M. “The plasmid profile, a useful marker in studying a focus of Salmonella enteritidis food poisoning.” Bacteriol Virusol Parazitol Epidemiol (1995) 40(3-4): 231-4

Begg EJ & Atkinson HC “Modeling of the passage of drugs into milk.” (1993) Pharmac & Ther 59, 301-310

Begg EJ, Atkinson HC & Duffull SB “Prospective evaluation of a model for the prediction of milk-plasma drug concentrations from physicochemical characteristics.” (1993) Br J Clin Pharmac 33, 501-6

Hickling KG, Begg EJ, Perry RE, Atkinson HC & Sharman JR “Serum aminoglycoside clearance is predicted poorly by renal aminoglycoside clearance as by creatinine clearance in critically ill patients” (1992) Critical Care Med 19, 1041-7

Atkinson HC & Duffull SB “Prediction of drug loss from PVC Infusion bags” (1991) J Pharm 43.374-6

Begg EJ & Atkinson HC “Partitioning of drugs into human milk.” (1991) Annals of Med, 20(1), 51-5

Robson RA, Begg EJ, Atkinson HC, Saunders DA & Framton CM “Comparative effects of ciprofloxacin and lomefloxacin on the oxidative metabolism of theophylline.” (1990) Br J Clin Pharm, 29, 491-3

Clin Pharmacokinet” (1990) 18(2) 151-167

Atkinson HC & Begg EJ “Prediction of drug distribution into human milk from physicochemical characteristics

Atkinson HC, Chambers St & McGinlay AM “Antibiotic therapy costs” (1989) NZ Med J 102, 409-11

Begg EJ, Atkinson HC et al. “Individualised aminoglycoside dosage based on pahrmacokinetic analysis is superior to dosage based on physician based intuition at achieving target plasma drug concentrations.” (1989) Br J Clin Pharm, 28, 137-141

Atkinson HC & Begg EJ “Relationship between human milk lipid-ultrafiltrate and octanol-water partition coefficients” (1988) Pharm Sci, 77, 796-8

Chapman MH, Woolner DF, Begg EJ, Atkinson HC& Sharman JR “Co-administered oral metoclopramide does not enhance the rate of absorption or oral diazepam.” (1988) Anaesth Intens Care, 16, 202-205

Atkinson HC & Begg EJ “The binding of drug to major human milk proteins.” (1988) Br J Clin Pharmac, 26, 107-109

Atkinson HC, Begg EJ and Darlow BA “Drugs in human milk-pharmacokinetic considerations.” (1988) Clin, Pharmcokinet. 14, 217-240.

Atkinson HC& Begg EJ “Prediction of drug concentration in human skim milk from plasma protein binding and acid-base characteristics.” (1988) Br J Clin Pharmac, 25, 495-503.

Atkinson HC & Begg EJ. “The Christchurch hospital drug information service: organisation and an audit of the first 300 questions answered”. (1987) NZ Med J, 100, 530-2

Begg EJ, Atkinson HC & Gianarakis N “The pharmacokinetics of corticosteroid agents” (1987) Aust Med J 146, 37-41.

Atkinson HC “Chloroform use in oral medicine.” (1986) NZ Med J 99, 555.